| Event Information
ChBE Distinguished Guest Seminar: Joseph M. DeSimone
Co-opting Moore’s Law: The Cost-effective Design of Vaccines and Therapeutics
Joseph M. DeSimone
In 1965, Gordon Moore, co-founder of Intel, described the trend that the number of components in integrated circuits had doubled every year since 1958. This trend has continued to today, enabled by advances in photolithography which has taken the minimum feature size of transistors down from about 10 microns in 1970 to 0.045 microns (45 nm) today. In biological terms, this corresponds to going from the size of a red blood cell to the size of a single virus particle! As such, this top-down nano-fabrication technology from the semiconductor industry is, for the first time, in the size range to be relevant for the design of medicines, vaccines and interfacially active Janus particles. This lecture will describe the design, synthesis and efficacy of organic nano- and micro-particles using a top-down nano-fabrication technique we developed called PRINT (Particle Replication in Non-wetting Templates). PRINT is a continuous, roll-to-roll, high resolution molding technique that allows the fabrication of precisely defined micro- and nano-particles in a continuous manner with control over chemical composition, size, shape, deformability and surface chemistry. With these ‘nanotools’, we are establishing definitive biodistribution maps to elucidate the interdependent roles that size, shape, deformability and surface chemistry play on particle distribution as a function of different dosage forms (IV, IP, inhaled, subcutaneous, intramuscular, etc). This information is setting the stage for the design of highly effective chemo-therapeutics, respiratory therapeutics and vaccines which will be described.
About the Speaker
DeSimone, an innovative polymer chemist, has made breakthrough contributions in green chemistry, fluoropolymer synthesis, colloid science and nano-biomaterials. He pioneered supercritical CO2-based polymerization reactions and the self-assembly of molecules in compressible media. He has shown the benefit of novel fluoro-elastomers for soft lithographic applications, including the synthesis of shape-controlled nano-biomaterials. DeSimone received his B.S. in Chemistry in 1986 from Ursinus College in Collegeville, Pa. and his Ph.D. in Chemistry in 1990 from Virginia Tech.
This Event is For: Clark School • Graduate • Undergraduate • Prospective Students • Faculty • Post-Docs